Resonance of His Call

The followers of the new religion start to grow, and so does the concern of the Quraysh towards them.  The elders of Quraysh send Abu Talib, the trusted uncle of the Prophet to him, asking him to stop his call for this new religion, and in return they would give him whatever he would want. “If you want wealth, we will give you as much as you want, if you want women we will marry you the most beautiful women of Arabia, and if you want position and status we will make you the owner-king over us.”  When Abu Talib conveys the message of the elders of Quraysh to his nephew-prophet, the Messenger of Allah replies, “I swear by the Almighty that if they put the Sun in my right hand and the Moon in my left on condition that I desist from this affair I would not leave it until Allah causes it to prevail or I die in the process.” Then the Messenger of Allah began to weep and rose and made to leave, but Abu Talib called him and said: ‘Come back my nephew. Say what you like my nephew, for by Allah I will never hand you over to them ever.'

The Quraysh realised that it is dealing with a true and determined prophet.  From then on, open hostility towards this new religion, its prophet, and its followers started to increase.  Lady Khadijah dedicates all her wealth and resources for the cause of her prophet-husband's mission.  The extent of this hostility reaches blatant persecution of the followers of the new religion and its prophet.

Reference : http://www.imamshirazi.com/prophet-biography.html#_Toc93317151